X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a phosphoramidate inhibitor MP1C

N-[(S)-[2-(benzoylamino)ethoxy](hydroxy)phosphoryl]-L-glutamic acid

Design of composite inhibitors targeting glutamate carboxypeptidase II: the importance of effector functionalities.

Cell growth-inhibiting gene 27 protein,Folate hydrolase 1,Folylpoly-gamma-glutamate carboxypeptidase,FGCP,Glutamate carboxypeptidase II,GCPII,Membrane glutamate carboxypeptidase,mGCP,N-acetylated-alpha-linked acidic dipeptidase I,NAALADase I,Prostate-specific membrane antigen,PSMA,Pteroylpoly-gamma-glutamate carboxypeptidase

33% (v/v) pentaerythritol propoxylate PO/OH 5/4, 0.5 % (w/v) PEG 3350, and 100 mM Tris-HCl, pH 8.0

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

glutamate carboxypeptidase II (E.C.3.4.17.21)

glutamate carboxypeptidase II (GCPII), NAALADase, prostate-specific membrane antigen, phosphoramidate, hydrolase