Structure of a nested set of N-terminally extended MHC I-peptides provides novel insights into antigen processing and presentation

ERAP1 enzyme-mediated trimming and structural analyses of MHC I-bound precursor peptides yield novel insights into antigen processing and presentation.

HLA class I histocompatibility antigen, B-8 alpha chain

0.2 M ammonium sulfate, 18% PEG4000, 0.1 M sodium cacodylate, pH 5.7

National Institutes of Health/National Human Genome Research Institute (NIH/NHGRI)

HLA class I histocompatibility antigen, B-8 alpha chain, Beta-2-microglobulin, ALA-ALA-ALA-LYS-LYS-LYS-TYR-CYS-LEU

MHC I antigen processing, MHC I antigen presentation, MHC I structure, MHC I immunopeptide, IMMUNE SYSTEM