Human DNA Ligase 1 Bound to an Adenylated, dideoxy Terminated DNA nick with 200 mM Mg2+

Two-tiered enforcement of high-fidelity DNA ligation.

DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*C)-3')

DNA (5'-D(*GP*TP*CP*CP*GP*AP*CP*GP*AP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3')

DNA ligase I,Polydeoxyribonucleotide synthase [ATP] 1

100 mM MES, 100 mM Lithium Acetate, 15% (w/v) polyethylene glycol 3350

National Institutes of Health/National Institute of Environmental Health Sciences (NIH/NIEHS)

protein-DNA complex, phosphotransferase, OB fold, DNA Binding domain, Adenylation Domain, metalloenzyme, LIGASE, LIGASE-DNA complex