Crystal structure of Mus musculus (Mm) Endonuclease V in complex with a 23mer RNA oligo containing an inosine after a 2 min soak in Mn2+

Evolution of Inosine-Specific Endonuclease V from Bacterial DNase to Eukaryotic RNase.

DNA/RNA (5'-R(P*CP*GP*GP*UP*AP*AP*CP*CP*C)-D(P*I)-R(P*AP*UP*AP*UP*GP*CP*AP*UP*GP*CP*AP*UP*U)-3')

polydeoxyribonucleotide/polyribonucleotide hybrid

0.2 M potassium sodium tartrate, 20-25% w/v PEG3350

Nucleic acid hydrolysis, RNA recognition, metal ion dependent catalysis, DNA damage, adenosine deamination, HYDROLASE

(chain A and (resseq 8:10 or resseq 13:14 or resseq 17:22 or resseq 24:53 or (resid 54 and (name N or name CA or name CB or name OG )) or (resid 55 and (name N or name CA or name CB or name CG or name CD1 or name C or name O )) or (resid 56 and (name N or name CA or name CB or name CG1 or name CG2)) or (resid 57 and (name O or name N or name CA or name C or name CB )) or resseq 61 or resseq 63:65 or resseq 67:71 or (resid 72 and (name N or name CA or name C or name O or name CB or name CG or name CD2 or name CE2 or name CZ or name OH )) or resseq 73:75 or resseq 77:82 or (resid 83 and (name N or name CA or name CB or name CG or name CD or name NE or name CZ or name NH1 or name NH2)) or resseq 84:86 or (resid 87 and (name O or name N or name C or name CB or name CG )) or resseq 89:97 or (resid 98 and (name N or name CA or name CB or name CG or name CD2 or name C or name O )) or (resid 99 and (name N or name CA or name CB or name CG or name CD or name NE or name CZ or name NH1 or name NH2)) or resseq 100 or resseq 102:105 or (resid 106 and (name N or name CA or name CB or name CG or name CD or name OE1 or name OE2)) or resseq 107:108 or resseq 110 or (resid 111 and (name N or name CA or name CB or name CG or name CD1 or name CD2)) or resseq 112:118 or (resid 119 and (name N or name CA or name CB or name CG or name SD or name CE )) or resseq 120:130 or (resid 131 and (name N or name CA or name CB or name CG or name CD2 or name CD1)) or resseq 132:149 or resseq 151:167 or (resid 168 and (name N or name CA or name CB or name CG or name CD2 or name C or name O )) or resseq 169:174 or (resid 175 and (name N or name CA or name CB or name CG or name CD1 or name C or name O )) or resseq 176:185 or (resid 186 and (name N or name C or name O or name CB or name CG1 or name CG2 or name CD1)) or resseq 187:194 or (resid 195 and (name N or name CA or name CB or name CG or name SD or name CE )) or resseq 196:199 or resseq 201:202 or (resid 204 and (name N or name CA or name CB or name OG1 or name CG2)) or resseq 205:213 or resseq 215:217 or (resid 218 and (name N or name CA or name C or name O )) or resseq 219:220 or resseq 222:228 or resseq 230:241 or resseq 243:251))

(chain B and (resseq 8:10 or resseq 13:14 or resseq 17:22 or resseq 24:53 or (resid 54 and (name N or name CA or name CB or name OG )) or (resid 55 and (name N or name CA or name CB or name CG or name CD1 or name C or name O )) or (resid 56 and (name N or name CA or name CB or name CG1 or name CG2)) or resseq 57 or resseq 61 or resseq 63:65 or resseq 67:71 or (resid 72 and (name N or name CA or name C or name O or name CB or name CG or name CD2 or name CE2 or name CZ or name OH )) or resseq 73:75 or resseq 77:82 or (resid 83 and (name N or name CA or name CB or name CG or name CD or name NE or name CZ or name NH1 or name NH2)) or resseq 84:86 or (resid 87 and (name N or name CA or name CB or name CG or name CD2)) or resseq 89:97 or (resid 98 and (name N or name CA or name CB or name CG or name CD2 or name C or name O )) or (resid 99 and (name N or name CA or name CB or name CG or name CD or name NE or name CZ or name NH1 or name NH2)) or resseq 100 or resseq 102:105 or (resid 106 and (name N or name CA or name CB or name CG or name CD or name OE1 or name OE2)) or resseq 107:108 or resseq 110 or (resid 111 and (name N or name CA or name CB or name CG or name CD1 or name CD2)) or resseq 112:118 or (resid 119 and (name N or name CA or name CB or name CG or name SD or name CE )) or resseq 120:130 or (resid 131 and (name N or name CA or name CB or name CG or name CD2 or name CD1)) or resseq 132:149 or resseq 151:167 or (resid 168 and (name N or name CA or name CB or name CG or name CD2 or name C or name O )) or resseq 169:174 or (resid 175 and (name N or name CA or name CB or name CG or name CD1 or name C or name O )) or resseq 176:185 or (resid 186 and (name N or name C or name O or name CB or name CG1 or name CG2 or name CD1)) or resseq 187:194 or (resid 195 and (name N or name CA or name CB or name CG or name SD or name CE )) or resseq 196:199 or resseq 201:202 or (resid 204 and (name N or name CA or name CB or name OG1 or name CG2)) or resseq 205:213 or resseq 215:217 or (resid 218 and (name N or name CA or name C or name O )) or resseq 219:220 or resseq 222:228 or resseq 230:241 or resseq 243:247 or (resid 248 and (name O or name N or name C or name CA or name CB )) or (resid 249 and (name O or name N or name CA or name C or name CB )) or resseq 250:251))