Crystal Structure of HIV-1 I50V, A71V Protease in Complex with the Protease Inhibitor Darunavir

Structural and thermodynamic basis of amprenavir/darunavir and atazanavir resistance in HIV-1 protease with mutations at residue 50.

Bent conical Si-mirror (Rh coated), Bent Ge(111) monochromator

126mM Phosphate buffer pH 6.2, 63mM Sodium Citrate, 18-33% Ammonium Sulfate, VAPOR DIFFUSION, HANGING DROP, temperature 295K

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

HIV-1 protease, inhibitor resistance, AIDS, Aspartyl protease, drug resistance, Hydrolase-Hydrolase Inhibitor complex