Crystal structure of E. coli threonyl tRNA synthetase in complex with a TM84 analogue

[(2~{S},4~{S},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-oxolan-2-yl]methoxy-~{N}-[(2~{S},3~{S})-2-azanyl-3-oxidanyl-butanoyl]phosphonamidic acid

Synthesis and evaluation of an agrocin 84 toxic moiety (TM84) analogue as a malarial threonyl tRNA synthetase inhibitor.

12% (w/v) PEG 4000, 21% (v/v) MPD, and 0.1 M sodium citrate

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

threonyl tRNA synthetase, e. coli, inhibitor, complex, RNA BINDING PROTEIN