Crystal Structure of 11beta-Hydroxysteroid Dehydrogenase-1 (11b-HSD1) in Complex with Diarylsulfone Inhibitor

NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
2'-MONOPHOSPHOADENOSINE 5'-DIPHOSPHORIBOSE

The synthesis and SAR of novel diarylsulfone 11beta-HSD1 inhibitors

Corticosteroid 11-beta-dehydrogenase isozyme 1

11-beta-hydroxysteroid dehydrogenase 1, 11-beta-HSD1, 11-DH

16% PEG 3350, 0.1 M MES 6.4, vapor diffusion, temperature 289K

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

Corticosteroid 11-beta-dehydrogenase isozyme 1 (E.C.1.1.1.146)

oxidoreductase, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex