Crystal structure of the 2-methylisocitrate lyase

Crystal structures of 2-methylisocitrate lyase in complex with product and with isocitrate inhibitor provide insight into lyase substrate specificity, catalysis and evolution.

1.6 M ammonium sulfate, 0.1M HEPES, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K

structural genomics, alpha-beta barrel, swapped helix across a dimer, Structure 2 Function Project, S2F, LYASE