Structure of Aedes aegypti OBP22 in the complex with arachidic acid

Aedes aegypti Odorant Binding Protein 22 selectively binds fatty acids through a conformational change in its C-terminal tail.

1.55M ammonium sulfate, 0.1M citric acid, 0.5M sodium chloride

National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)

Structure of AeOBP22 bound to linoleic acid

Structure of AeOBP22 bound to arachidonic acid

Structure of AeOBP22 bound to palmitoleic acid

NMR relaxation experiments establish the overall correlation time is consistent with the presence of a monomeric species in solution. The dimeric form appears to be a crystallization artifact.

HYDROGENS HAVE BEEN USED IF PRESENT IN THE INPUT

Odorant binding protein, Chemo-sensory signaling, Lipid binding, TRANSPORT PROTEIN