Crystal structure of D52N/R367Q cN-II mutant bound to dATP and free phosphate

Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation.

0.1 M MES/imidazole pH 6.5; 0.03 M of each divalent cation; 10% w/v PEG 8000, 20% v/v ethylene glycol (Morpheus condition A2)

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES : WITH TLS ADDED

Cytosolic purine 5'-nucleotidase (E.C.3.1.3.5)

nucleotidase, relapsed leukemia, HYDROLASE