Crystal Structure of L100I Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X.

S-CYSTEINESULFINIC ACID; S-SULFINOCYSTEINE

ISOPROPYL (2S)-2-ETHYL-7-FLUORO-3-OXO-3,4-DIHYDROQUINOXALINE-1(2H)-CARBOXYLATE

Relationship of Potency and Resilience to Drug Resistant Mutations for GW420867X Revealed by Crystal Structures of Inhibitor Complexes for Wild-Type, Leu100Ile, Lys101Glu, and Tyr188Cys Mutant HIV-1 Reverse Transcriptases.

pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 277K

HIV-1 REVERSE TRANSCRIPTASE, AIDS, NNRTI, GW420867X, DRUG RESISTANCE, TRANSFERASE