Structural basis for the auto-inhibition of c-Abl tyrosine kinase

Structural basis for the autoinhibition of c-Abl tyrosine kinase

A myristoyl/phosphotyrosine switch regulates c-Abl

Proto-oncogene tyrosine-protein kinase ABL1

20% PEG 3350, 200 mM potassium nitrate, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K

C-ABL KINASE DOMAIN IN COMPLEX WITH A MYRISTOYLATED PEPTIDE

SEQUENCE
Numbering of the residues corresponds to the
sequence database numbering of the isoform IV
of the protein.