The X-ray crystal structure of the 67kDa isoform of Glutamic Acid Decarboxylase (GAD67)

(2S)-2-amino-6-[[3-hydroxy-2-methyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]hexanoic acid

4-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]BUTANOIC ACID

GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop.

Glutamate decarboxylase 67 kDa isoform, GAD-67, 67 kDa glutamic acid decarboxylase

18% PEG8,000, 100 mM MES, pH 6.3, 10 mM 2-mercaptoethanol and 20 mM CaCl2, VAPOR DIFFUSION, HANGING DROP, temperature 293K

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

Glutamate decarboxylase 1 (E.C.4.1.1.15)

The biological unit corresponds to the dimer in the asymmetric unit.