Human GKRP bound to AMG-0771 and sorbitol-6-phosphate

1-O-PHOSPHONO-D-GLUCITOL, D-GLUCITOL-6-PHOSPHATE

Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine series.

0.1M Bis-tris, 0.2M NaI, 16%PEG 8000, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

SIS domain containing protein, Binds and inhibits glucokinase, Glucokinase, liver, CARBOHYDRATE BINDING PROTEIN-INHIBITOR complex