PQR530 [(S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine] bound to the PI3Ka catalytic subunit p110alpha

(S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable Dual Inhibitor of Class I PI3K and mTOR Kinase.

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

PtdIns-3-kinase subunit alpha,Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha,p110alpha,Phosphoinositide-3-kinase catalytic alpha polypeptide,Serine/threonine protein kinase PIK3CA

8% PEG6000, 0.6M Na Formate, 0.1M CHES pH 9.5, 5mM TCEP

Canadian Institutes of Health Research (CIHR)

Ras-related protein Rab-11A, SH3 domain-binding protein 5

PIK3CA, mTOR, phosphoinositide, PIP3, PI3K, p110, SIGNALING PROTEIN, TRANSFERASE