Crystal structure of Csm6 in complex with cdA4 by soaking cdA4 into Csm6

CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering Stepwise cA4Cleavage with ApA>p Formation Terminating RNase Activity.

10% PEG 8K, 0.2 M NaCl, 0.1 M
Na/K phosphate pH 6.2

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

Type III-A CRISPR-Cas system; Csm6 in complex with cdA4, IMMUNE SYSTEM, immune system-dna complex