Crystal Structure of Human IDO1 bound to navoximod (NLG-919)

Discovery of Clinical Candidate (1R,4r)-4-((R)-2-((S)-6-Fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexan-1-ol (Navoximod), a Potent and Selective Inhibitor of Indoleamine 2,3-Dioxygenase 1.

IDO-1,Indoleamine-pyrrole 2,3-dioxygenase

0.1 M Bis Tris propane pH 6.5, 20% PEG 3350, 0.2 M potassium thiocyanate

Active as monomer. Forms dimer in crystallographic asu.

Indoleamine 2,3-dioxygenase 1 (E.C.1.13.11.52)

Dioxygenase, tryptophan, IDO, TDO, OXIDOREDUCTASE-INHIBITOR complex