Structural Basis for Formation and Hydrolysis of Calcium Messenger Cyclic ADP-ribose by Human CD38

Structural basis for formation and hydrolysis of the calcium messenger cyclic ADP-ribose by human CD38

Cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, Lymphocyte differentiation antigen CD38, T10, Acute lymphoblastic leukemia cells antigen CD38

100 mM MES, 12% PEG4000, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 300K

There are two biological units in the crystallographic asymmetric unit.

Human CD38 E226Q mutant, the catalytic pocket, cADPR formation and hydrolysis, substrate binding, HYDROLASE