The crystal structure of a mutant NAMPT (S165F) in complex with GNE-618

Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors.

NAmPRTase, Nampt, Pre-B-cell colony-enhancing factor 1, Pre-B cell-enhancing factor, Visfatin

0.1M Sodium phosphate, pH 8.6, 25% polyethylene glycol 3350, 0.2M NaCl and 1mM compound, VAPOR DIFFUSION, SITTING DROP, temperature 292K

( CHAIN A AND ( RESID 8:487 OR RESID 603:604 ) ) OR ( CHAIN B AND ( RESID 8:487 OR RESID 603:605 ) )

Nicotinamide phosphoribosyltransferase (E.C.2.4.2.12)

TRANSFERASE-TRANSFERASE INHIBITOR complex