Deoxy hemoglobin (A-GLYGLYGLY-C:V1M,L29F,H58Q B,D:V1M,V67W)

Genetically Crosslinked Hemoglobin: A Structural Study

Rate of Reaction with Nitric Oxide Determines the Hypertensive Effect of Cell-Free Hemoglobin

A Human Recombinant Hemoglobin Designed for Use as a Blood Substitute

CYANOMET HEMOGLOBIN (A-GLY-C:V1M,L29F,H58Q; B,D:V1M,L106W)

DEOXY HEMOGLOBIN (A-GLY-C:V1M,L29F,H58Q; B,D:V1M,L106W)

DEOXY HEMOGLOBIN (A,C:V1M; B,D:V1M,V67W)

DEOXY HEMOGLOBIN (A-GLY-C:V1M,L29W,H58Q; B,D:V1M)

DEOXY HEMOGLOBIN (A-GLYGLYGLY-C:V1M,L29W; B,D:V1M)

DEOXY HEMOGLOBIN (A,C:V1M,V67L; B,D:v1m, v67l)

DEOXY HEMOGLOBIN (A-GLY-C:V1M; B,D: v1m, c93a, n108k)

SEQUENCE
HUMAN HEMOGLOBIN HAS TWO ALPHA CHAINS WHICH ARE CALLED
CHAINS A AND C IN OTHER PDB FILES. IN THIS ENTRY THE
C-TERMINUS OF THE ALPHA-1 CHAIN AND THE N-TERMINUS OF THE
ALPHA-2 CHAIN ARE GENETICALLY LINKED BY THREE GLYCINE
RESIDUES TO FORM ONE COVALENTLY LINKED POLYPEPTIDE CHAIN.
THESE THREE RESIDUES ARE HIGHLY DISORDERED, I.E. NOT
DEFINED IN ELECTRON DENSITY. ALSO, THE INITIAL RESIDUE
OF THE ALPHA-2 CHAIN, JUST AFTER THE GLYCINE LINKER, IS
THE NATIVE VALINE, NOT A METHIONINE. THEREFORE, THE THREE
GLYCINE LINKER IS NOT INCLUDED IN THESE COORDINATES, AND
THE INITIAL RESIDUE OF THE ALPHA CHAIN(S) IS MODELED AS AN
ALANINE.

MOEWS & KRETSINGER, J.MOL.BIOL. 91(1973) 201-228

HEME, OXYGEN DELIVERY VEHICLE, BLOOD SUBSTITUTE, OXYGEN STORAGE-TRANSPORT COMPLEX