2.22A STRUCTURE OF THIOPHENE2 AND GSK945237 WITH S.AUREUS DNA GYRASE AND DNA

Thiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyrase.

DNA gyrase subunit B,DNA gyrase subunit B,DNA gyrase subunit A

DNA (5'-D(*AP*GP*CP*CP*GP*TP*AP*GP*GP*TP*AP*CP*CP*TP*AP*CP*GP*GP*CP*T)-3')

DNA gyrase subunit B, DNA gyrase subunit A/DNA Complex

TYPE IIA TOPOISOMERASE, ANTIBACTERIAL, INHIBITOR, ISOMERASE