Ternary complex crystal structure of K289M variant of DNA polymerase Beta with dGTP

Revealing an Internal Stabilization Deficiency in the DNA Polymerase beta K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography.

DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3')

DNA (5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3')

16-18% PEG 3350, 50 mM Imidazole, 350 mM Sodium Acetate

DNA Polymerase Beta, Conformational Change, enzyme mechanism, K289M, LFER, TRANSCRIPTION, transcription-dna complex