Structure of Interleukin 23 in complex with Briakinumab FAb

Structural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate IL-23 Receptor Enables Recruitment of the Shared Receptor IL-12R beta 1.

PETRA III, EMBL c/o DESY BEAMLINE P14 (MX2)

First 22 amino acids form the signal peptide.

First 19 amino acids form the signal peptide. Last 9 amino acids are a cloning scar and purification tag.

first 28 amino acids form the signal peptide

First 28 amino acids form the signal peptide. Last 41 amino acids are a cloning scar and the purification tag. Last 33 amino acids were removed by thrombin digestion.

IL-12B,Cytotoxic lymphocyte maturation factor 40 kDa subunit,CLMF p40,IL-12 subunit p40,NK cell stimulatory factor chain 2,NKSF2

IL-23-A,Interleukin-23 subunit p19,IL-23p19

Molecular Dimensions Cooled Crystallisation Incubators

(chain 'A' and resid 23:328) or (chain 'A' and resi 401:405)
(chain 'C' and resid 23:328) or (chain 'C' and resi 401:405)
(chain 'E' and resid 23:328) or (chain 'E' and resi 401:405)
(chain 'G' and resid 23:327) or (chain 'G' and resi 401:405)
(chain 'I' and resid 23:328) or (chain 'I' and resi 401:405)
(chain 'K' and resid 23:328) or (chain 'K' and resi 401:405)
SEC-MALLS show the 1:1 binding of the briakinumab FAb to the IL-23 cytokine.
composite model 4OE8 and homology model for FAb
Briakinumab FAb light chain, Briakinumab FAb heavy chain
antagonist, antibody, extracellular region, Immune system