Crystal structure of L-Trp/Indoleamine 2,3-dioxygenagse 1 (hIDO1) complex with the JK-loop refined in the closed conformation

2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.

(2S)-2-amino-4-[2-(formylamino)phenyl]-4-oxobutanoic acid

Temporary Intermediates of L-Trp Along the Reaction Pathway of Human Indoleamine 2,3-Dioxygenase 1 and Identification of an Exo Site.

IDO-1,Indoleamine-pyrrole 2,3-dioxygenase

15.4% PEG 3350
0.1M Phosphate buffer pH 6.0
Protein : 5mM HEPES pH 7.4, 200mM NaCl, 5mM DTT

L-Trp metabolism, hemoprotein, dynamics loop, OXIDOREDUCTASE