BG505 MD64 N332-GT5 SOSIP trimer in complex with BG18-like precursor HMP1 fragmentantigen binding and base-binding RM20A3 fragment antigen binding

A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses.

Detergent (DDM) added immediately prior to grid preparation

BG505 MD64 N332-GT5 SOSIP trimer in complex with BG18-like precursor HMP1 fragment antigen binding and base-binding 8D11 fragment antigen binding

HIV-1 Env BG505 MD64 N332-GT5 SOSIP gp120

HIV-1 Env BG505 MD64 N332-GT5 SOSIP gp41

BG18-like precursor HMP1 fragment antigen binding heavy chain

BG18-like precursor HMP1 fragment antigen binding light chain

base-binding RM20A3 fragment antigen binding heavy chain

base-binding RM20A3 fragment antigen binding light chain

National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)

The EM map was reconstructed with C3 symmetry imposed, and the same C3 symmetry was used during Rosetta Relax model refinement

HIV-1 Env BG505 MD64 N332-GT5 SOSIP gp120, HIV-1 Env BG505 MD64 N332-GT5 SOSIP gp41, BG18-like precursor HMP1 fragment antigen binding heavy chain, V2-17 protein, base-binding RM20A3 fragment antigen binding heavy chain, base-binding RM20A3 fragment antigen binding light chain
HIV-1, HIV Envelope, SOSIP, antibody, trimer, precursor antibody, VIRAL PROTEIN, VIRAL PROTEIN-immune system complex