Crystal structure of the Fab fragment of therapeutic antibody daclizumab in complex with IL-2Ra (CD25) ectodomain

Structural basis of immunosuppression by the therapeutic antibody daclizumab

Heavy chain of Fab fragment of daclizumab

Light chain of Fab fragment of daclizumab

IL-2 receptor subunit alpha, IL-2R subunit alpha, IL-2-RA, IL2-RA, p55, TAC antigen, CD_antigen=CD25

purchased from Roche, expressed in a mammalian expression system

0.1 M Tris-HCl, 0.2M MgCl2, 10% PEG 8000, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K

Heavy chain of Fab fragment of daclizumab, Light chain of Fab fragment of daclizumab, Interleukin-2 receptor subunit alpha

IL-2Ra, CD25, Daclizumab, Zenapax, therapeutic antibody, immune system, Immune system-Cytokine complex