Binary complex crystal structure of DNA polymerase Beta with 5-carboxy-dC (5-caC) at the templating position

5-carboxy-2'-deoxycytidine monophosphate

Molecular basis for the faithful replication of 5-methylcytosine and its oxidized forms by DNA polymerase beta.

DNA (5'-D(*CP*CP*GP*AP*CP*(1CC)P*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3')

DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3')

7.5, 50 mM Imidazole, 350 mM Sodium Acetate

DNA Polymerase Beta, Conformational Change, enzyme mechanism, epigenetic modifications, GENE REGULATION, gene regulation-dna complex