Crystal Structure of Substrate Complex of Putative Pteridine Reductase 2 (PTR2) from Trypanosoma cruzi

NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
2'-MONOPHOSPHOADENOSINE 5'-DIPHOSPHORIBOSE

Crystal structure of Trypanosoma cruzi pteridine reductase 2 in complex with a substrate and an inhibitor.

Expression, purification, crystallization and preliminary crystallographic analysis of recombinant pteridine reductase of Trypanosoma cruzi

Sodium acetate, cacodylate buffer, pH 6.50, temperature 293K

Crystal Structure of Leishmania major PTR1 (Inhibitor Complex)

Crystal Structure of Leishmania major PTR1 (Substrate Complex)

Crystal Structure of Trypanosoma cruzi PTR2 (Inhibitor Complex)

Heterogen
Ligand coordinates were taken from PDB entry 1RF7.
The coordinate file was missing a carboxylate group
in the glutamate portion. No correction was made
since the glutamate portion of ligand DHF shows no
clear density in this structure.

INHIBITOR COMPLEX SOLVED BY MAD METHOD (PDBID 1MXF)

PTERIDINE REDUCTASE 2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, DIHYDROFOLIC ACID

SDR TOPOLOGY, PROTEIN-SUBSTRATE COMPLEX, OXIDOREDUCTASE