Crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (IspF) Burkholderia pseudomallei in complex with ligand HGN-0863

Seattle Structural Genomics Center for Infectious Disease (SSGCID)

Crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (IspF) Burkholderia pseudomallei in complex with ligand HGN-0456.

2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

Burkholderia pseudomallei (strain 1710b)

Optimization screen Bups122_quad_2, condition c4: 200mM Ammonium acetate, 100mM HEPES free acid/NaOH pH 7.5, 26% PEG 3350: BupsA.00122.a.A1.PW28612 at 14mg/ml + 9mM compound bsi108668/HGN-0863: Cryo: 20% EG: Tray 302680c4, puck NZC8-7

Seattle Structural Genomics Center for Infectious Disease
NIAID, National Institute of Allergy and Infectious Diseases

2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (E.C.4.6.1.12)

SSGCID, Structural Genomics, Seattle Structural Genomics Center for Infectious Disease, LYASE