Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-{3-[(3,5-dichlorobenzyl)amino]propyl}-3-(2-hydroxyphenyl)urea (Chem 1392)

Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness.

1.00 degrees, 5.0 sec, detector distance 295.00 mm

2.0-2.3 M ammonium sulfate, 0.2 M sodium chloride, 0.1 M sodium cacodylate, pH 6.0-6.8, VAPOR DIFFUSION, SITTING DROP, temperature 298K

methionyl-tRNA synthetase in complex with substrate methionine

methionyl-tRNA synthetase in complex with intermediate product methionyl-adenylate

methionyl-tRNA synthetase in complex with inhibitor Chem 1312

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

Methionyl-tRNA synthetase (E.C.6.1.1.10)

aminoacyl-tRNA synthetase, aaRS, MetRS, parasite, protein-inhibitor complex, Rossmann fold, translation, nucleotide binding, LIGASE-LIGASE INHIBITOR complex