CryoEM Structure of Full-Length mGlu2 Bound to Ago-PAM ADX55164 and Glutamate

N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE

G-protein activation by a metabotropic glutamate receptor.

Metabotropic glutamate receptor 2 bound to ago-PAM ADX55164 and L-Glutamate
Full-length mGlu2 in ago-PAM and L-Glutamate bound-state

Lys751 on Chain A and Asn757 on Chain B are modeled and nearby residues are refined. The sidechain rotamer of Trp697 on Chain A is adjusted. Six side chains are stubbed.

National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS)

Metabotropic Glutamate Receptor 2 (mGlu2) (mGluR2), Family C G protein-coupled receptor (GPCR), Heterotrimeric G protein, CryoEM structure, MEMBRANE PROTEIN, MEMBRANE PROTEIN-AGONIST complex