CRYSTAL STRUCTURE OF NATIVE BOVINE ARRESTIN 1 IN COMPLEX WITH 1D-MYO-INOSITOL 1,5-BISDIPHOSPHATE TETRAKISPHOSPHATE (1,5-PP IP4)

(1R,3S,4R,5S,6R)-2,4,5,6-tetrakis(phosphonooxy)cyclohexane-1,3-diyl bis[trihydrogen (diphosphate)]
1D-myo-inositol 1,5-bisdiphosphate 2,3,4,6-tetrakisphosphate

Structural evidence for visual arrestin priming via complexation of phosphoinositols.

48 kDa protein,Retinal S-antigen,S-AG,Rod photoreceptor arrestin

0.1 M Bis-Tris propane, 35% 2-Ethoxyethanol, 0.001 mM Magnesium acetate, 5 mM 1D-MYO-INOSITOL 1,5-BISDIPHOSPHATE TETRAKISPHOSPHATE

National Institutes of Health/National Eye Institute (NIH/NEI)

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES : REFINED INDIVIDUALLY

GPCR, rhodopsin, phototransduction, inositol, 1, 5PP-IP4, IP8, PROTEIN BINDING