Signal subtracted reconstruction of AAA2, AAA3, and AAA4 domains of dynein in the presence of a pyrazolo-pyrimidinone-based compound, Model 4

Targeting allostery in the Dynein motor domain with small molecule inhibitors.

Dynein motor domain in the presence of a pyrazolo-pyrimidinone-based compound

National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)

AAA ATPase, ATPase inhibitor, Motor Protein