Hepatitis C virus polymerase NS5B (BK) with amide bioisostere thumb site inhibitor

3-[2-(trans-4-methylcyclohexyl)phenyl]-5-phenylthiophene-2-carboxylic acid

Cyclic amide bioisosterism: Strategic application to the design and synthesis of HCV NS5B polymerase inhibitors.

26% PEG 4000, 7.5% glycerol, 50 mM Na citrate pH 4.9, VAPOR DIFFUSION, SITTING DROP, temperature 273K

Hepatitis C virus RNA-dependent RNA polymerase NS5B with NNI-1 inhibitor

RNA-directed RNA polymerase (E.C.2.7.7.48)

HCV, HEPATITIS, NS5B, TRANSFERASE RNA-DEPENDENT RNA POLYMERASE, TRANSFERASE