CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH ACTIVE SITE AND EXOSITE BINDING PEPTIDE INHIBITOR

Potent and Selective BACE-1 Peptide Inhibitors Lower Brain A beta Levels Mediated by Brain Shuttle Transport.

BACE-1 ACTIVE AND EXOSITE BINDING INHIBITOR

Aspartyl protease 2,Asp 2,Beta-site amyloid precursor protein cleaving enzyme 1,Beta-site APP cleaving enzyme 1,Memapsin-2,Membrane-associated aspartic protease 2

0.1M magnesium acetate, 0.1M sodium acetate, 8% (w/v) PEG8000

Beta-secretase 1 (E.C.3.4.23.46), BACE1 INHIBITOR PEPTIDE Pep#3

PROTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, HYDROLASE, EXOSITE

binding site for Ligand residues STA D 671 through VAL D 672 bound to ASN D 670