Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and Pimasertib

PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER

Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation.

Dual specificity mitogen-activated protein kinase kinase 1

MKK1,ERK activator kinase 1,MAPK/ERK kinase 1,MEK 1

Proto-oncogene B-Raf,p94,v-Raf murine sarcoma viral oncogene homolog B1

100 mM Tris 8.5, 200 mM Lithium Sulfate and 22% PEG 3,350

National Institutes of Health/National Cancer Institute (NIH/NCI)