Structure of SARS-CoV-2 3CL protease in complex with inhibitor 12b

(1R,2S)-2-((S)-2-((((S)-1-(4,4-difluorocyclohexyl)ethoxy)carbonyl)amino)-4-methylpentanamido)-1-hydroxy-3-((S)-2-oxopyrrolidin-3-yl)propane-1-sulfonic acid

(1S,2S)-2-((S)-2-((((S)-1-(4,4-difluorocyclohexyl)ethoxy)carbonyl)amino)-4-methylpentanamido)-1-hydroxy-3-((S)-2-oxopyrrolidin-3-yl)propane-1-sulfonic acid

Structure-Guided Design of Potent Inhibitors of SARS-CoV-2 3CL Protease: Structural, Biochemical, and Cell-Based Studies.

3CL-PRO, 3CLp, Main protease, Mpro, Non-structural protein 5, nsp5, SARS coronavirus main proteinase

Severe acute respiratory syndrome coronavirus 2

National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)

COVID-19, PROTEASE, severe acute respiratory syndrome coronavirus 2, SARS-CoV-2 3CL protease Inhhibitors, HYDROLASE-INHIBITOR complex