CRYSTAL STRUCTURE OF M184V MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE

S-CYSTEINESULFINIC ACID; S-SULFINOCYSTEINE

Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215.

Structural Mechanisms of Drug Resistance for Mutations at Codons 181 and 188 in HIV-1 Reverse Transcriptase and the Improved Resilience of Second Generation Non-Nucleoside Inhibitors

2-Amino-6-Arylsulfonylbenzonitriles as Non-Nucleoside reverse Transcriptase Inhibitors of HIV-1

Structural Basis for the Resilience of Efavirenz (Dmp-266) to Drug Resistance Mutations in HIV-1 Reverse Transcriptase

Binding of the Second Generation Non-Nucleoside Inhibitor S-1153 to HIV-1 Reverse Transcriptase Involves Extensive Main Chain Hydrogen Bonding

Phenethylthiazolylthiourea (Pett) Non-Nucleoside Inhibitors of HIV-1 and HIV-2 Reverse Transcriptases. Structural and Biochemical Analyses

Crystallographic Analysis of the Binding Modes of Thiazoloisoindolinone Non-Nucleoside Inhibitors to HIV-1 Reverse Transcriptase and Comparison with Modeling Studies

Design of Mkc-442 (Emivirine) Analogues with Improved Activity Against Drug-Resistant HIV Mutants

Crystal Structures of HIV-1 Reverse Transcriptase in Complex with Carboxanilide Derivatives

3'-Azido-3'-Deoxythymidine Drug Resistance Mutations in HIV-1 Reverse Transcriptase Can Induce Long Range Conformational Changes

Continuous and Discontinuous Changes in the Unit Cell of HIV-1 Reverse Transcriptase Crystals on Dehydration

Unique Features in the Structure of the Complex between HIV-1 Reverse Transcriptase and the Bis(Heteroaryl)Piperazine (Bhap) U-90152 Explain Resistance Mutations for This Non-Nucleoside Inhibitor

Complexes of HIV-1 Reverse Transcriptase with Inhibitors of the HEPT Series Reveal Conformational Changes Relevant to the Design of Potent Non-Nucleoside Inhibitors

The Structure of HIV-1 Reverse Transcriptase Complexed with 9-Chloro-TIBO: Lessons for Inhibitor Design

High Resolution Structures of HIV-1 RT from Four RT-Inhibitor Complexes

Mechanism of Inhibition of HIV-1 Reverse Transcriptase by Non-Nucleoside Inhibitors

Crystals of HIV-1 Reverse Transcriptase Diffracting to 2.2 A Resolution

pH 5.00, VAPOR DIFFUSION, SITTING DROP, temperature 277K

1VRT contains the same protein COMPLEXED WITH NEVIRAPINE

1RTH contains the same protein COMPLEXED WITH 1051U91

1VRU contains the same protein COMPLEXED WITH ALPHA-APA

1RTI contains the same protein COMPLEXED WITH HEPT

1REV contains the same protein COMPLEXED WITH 9-CL-TIBO

1RT1 contains the same protein COMPLEXED WITH MKC-442

1RT2 contains the same protein COMPLEXED WITH TNK-651

1KLM contains the same protein COMPLEXED WITH BHAP (U-90152)

1RT3 contains AZT DRUG RESISTANT HIV-1 RT MUTANT (RTMC) COMPLEXED WITH 1051U91

1RT4 contains the same protein COMPLEXED WITH UC-781

1RT5 contains the same protein COMPLEXED WITH UC-10

1RT6 contains the same protein COMPLEXED WITH UC-38

1RT7 contains the same protein COMPLEXED WITH UC-84

1C0T contains the same protein COMPLEXED WITH BM+21.1326

1C0U contains the same protein COMPLEXED WITH BM+50.0934

1C1B contains the same protein COMPLEXED WITH GCA-186

1C1C contains the same protein COMPLEXED WITH TNK-6123

1DTQ contains the same protein COMPLEXED WITH PETT-1

1DTT contains the same protein COMPLEXED WITH PETT-2

1EP4 contains the same protein COMPLEXED WITH S-1153

1FK9 contains the same protein COMPLEXED WITH DMP-226 (EFAVIRENZ)

1FKO contains K103N MUTANT HIV-1 RT COMPLEXED WITH DMP-226 (EFAVIRENZ)

1FKP contains K103N MUTANT HIV-1 RT COMPLEXED WITH NEVIRAPINE

1JLA contains Y181C MUTANT HIV-1 RT COMPLEXED TNK-651

1JLB contains Y181C MUTANT HIV-1 RT COMPLEXED WITH NEVIRAPINE

1JLC contains Y181C MUTANT HIV-1 RT COMPLEXED WITH PETT-2

1JLF contains Y188C MUTANT HIV-1 RT COMPLEXED WITH NEVIRAPINE

1JLG contains Y188C MUTANT HIV-1 RT COMPLEXED WITH UC-781

1JKH contains Y181C MUTANT HIV-1 RT COMPLEXED WITH DMP-226 (EFAVIRENZ)

1JLQ contains the same protein COMPLEXED WITH 739W94

1LW0 contains T215Y MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE

1LW2 contains T215Y MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH 1051U91

1LWE contains M41L/T215Y MUTANT HIV-1 REVERSE TRANSCRIPTASE (RTMN) IN COMPLEX WITH NEVIRAPINE

1LWF contains MUTANT HIV-1 REVERSE TRANSCRIPTASE (RTMQ+M184V: M41L/D67N/K70R/M184V/T215Y) IN COMPLEX WITH NEVIRAPINE

HIV-1 RT is a heterodimer consisting of a p66 and a p51 subunits, the p51 contains the first 440 residues of the p66.

HIV-1 REVERSE TRANSCRIPTASE, AIDS, AZT, 3TC, NRTI, NEVIRAPINE, DRUG RESISTANCE MUTATIONS, TRANSFERASE