Fragment-based Identification of Amides Derived From trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)

Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).

NAmPRTase, Nampt, Pre-B-cell colony-enhancing factor 1, Pre-B cell-enhancing factor, Visfatin

0.2uL + 0.2uL drops containing 6mg/mL Nampt, 0.1M Sodium phosphate, 25-29% polyethylene glycol 3350, 0.2M NaCl, pH 8.6, VAPOR DIFFUSION, HANGING DROP, temperature 292K

( CHAIN A AND ( RESID 8:487 OR RESID 603:603 ) ) OR ( CHAIN B AND ( RESID 8:486 OR RESID 603:604 ) )

Nicotinamide phosphoribosyltransferase (E.C.2.4.2.12)

Transferase, TRANSFERASE-TRANSFERASE INHIBITOR complex