Structural basis for feedback and pharmacological inhibition of Saccharomyces cerevisiae glutamate cysteine ligase.

Gamma-glutamylcysteine synthetase, Gamma-ECS, GCS

100mM Hepes, pH 6.8, 14-20% PEG 400, 5mM GSH, 5mM MgCl2 , VAPOR DIFFUSION, SITTING DROP, temperature 291K

Glutamate--cysteine ligase (E.C.6.3.2.2)

Ligase, glutathione, atp-grasp, atp-binding, glutathione biosynthesis, nucleotide-binding, Phosphoprotein