Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and polyubiquitinated Ub-Eos (FOM, Class 3)

Mechanistic insight into substrate processing and allosteric inhibition of human p97.

Residues LEU 464 and ARG 465 that are next to each other in the sample sequence of chains B, C, D, and E are not properly linked.

Human p97 in complex with Npl4/Ufd1 and K48-linked polyubiquitinated Ub-Eos in the presence of ATP

Transitional endoplasmic reticulum ATPase

TER ATPase,15S Mg(2+)-ATPase p97 subunit,Valosin-containing protein,VCP

p97, NMS-873, single-particle cryo-EM, translocation, allosteric inhibition, TRANSLOCASE