CTX-M-9 in complex with the broad spectrum inhibitor 3-(2- carboxyvinyl)benzo(b)thiophene-2-boronic acid

(2E)-3-[2-(dihydroxyboranyl)-1-benzothiophen-3-yl]prop-2-enoic acid

Targeting Class A and C Serine beta-Lactamases with a Broad-Spectrum Boronic Acid Derivative.

Beta-lactamase CTX-M, Beta-lactamase CTX-M-9a, Betalactamase CTX-M-9, CTX-M-9 beta-lactamase, CTX-M-9 extended-spectrum beta-lactamase

blaCTX-M-9, blaCTX-M-9a, blaCTX-M-9a blaCTX-M-9 blaCTX-M-9b, blaCTX-M-9b

1.4 M potassium phosphate buffer using microseeding techniques, VAPOR DIFFUSION, HANGING DROP, temperature 295K, pH 8.8

THE STARTING MATERIAL USED FOR CHEMICAL REACTION CORRESPONDS TO THE COMPUND: 3-[2-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-BENZO[B]THIOPHEN-3-YL]-ACRYLIC ACID. SEE ALSO LINK RECORDS.

Binding Sites, structure base drug design, Drug Discovery, Molecular, Enzyme Inhibitors, beta lactamases, boronic acids, broad spectrum, bacterial resistance, double perturbation cycle analysis, thermodynamics, structure activity relationship, hydrolase-hydrolase inhibitor complex