Orexin Receptor 2 (OX2R) in Complex with G Protein and Small-Molecule Agonist Compound 1

Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation.

Gold standard with masking effect correction

40 frames with total 2s exposure per movie

Engineered Guanine nucleotide-binding protein subunit alpha

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

single-chain antibody Fv fragment (svFv16)

Engineered Guanine nucleotide-binding protein subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, single-chain antibody Fv fragment (svFv16), Hypocretin receptor type 2, Synthetic nanobody 51 (Sb51)

Class A GPCR, Orexin receptor 2, OX2R, membrane protein, Peptide agonist