Crystal Structures of Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors

Discovery of (Thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer.

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

PI3-kinase p110 subunit gamma, PtdIns-3-kinase subunit p110, PI3Kgamma, PI3K, p120-PI3K

PEG 3350, 0.2M NH4SO4, 0.1M Tris-HCl 8.5, vapor diffusion, hanging drop, temperature 289K

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (E.C.2.7.1.153)

kinase, ATP-binding, Nucleotide-binding, Transferase, PI3K-gamma p110 gamma