Efforts towards the optimization of a bi-aryl class of potent IRAK4 inhibitors.

Interleukin-1 receptor-associated kinase 4

IRAK-4,Renal carcinoma antigen NY-REN-64

1.80 to 2.0 M Sodium Malonate, 0.2 M Sodium Acetate, 25 mM Hexamminecobalt(III)chloride, 0.05%w/v Pluronic-F-68

Interleukin-1 receptor-associated kinase 4 (E.C.2.7.11.1)

KINASE, PHOSPHATASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX