Structure of ClpP in complex with ADEP2 in monoclinic crystal form

2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID

Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism

ATP-dependent Clp protease proteolytic subunit

Endopeptidase Clp, Caseinolytic protease, Stress protein G7

0.1M CHES, 200mM NaCl, 10% PEG 8000, pH 9.5, hanging drop, temperature 295K

CLPP in complex with ADEP2 in triclinic crystal form

ADEP2 IS A SYNTHETIC OPTIMIZED CONGENERS OF THE NATURAL PRODUCT ADEP1

ATP-dependent Clp protease proteolytic subunit (E.C.3.4.21.92), ADEP2

hydrolase, Protease, Serine protease, Stress response, A54556A, enopeptin, depsipeptide, antibiotics, HYDROLASE-ANTIBIOTIC complex

BINDING SITE FOR CHAIN H OF ACYLDEPSIPEPTIDE 2

BINDING SITE FOR CHAIN I OF ACYLDEPSIPEPTIDE 2

BINDING SITE FOR CHAIN J OF ACYLDEPSIPEPTIDE 2

BINDING SITE FOR CHAIN K OF ACYLDEPSIPEPTIDE 2

BINDING SITE FOR CHAIN L OF ACYLDEPSIPEPTIDE 2

BINDING SITE FOR CHAIN M OF ACYLDEPSIPEPTIDE 2

BINDING SITE FOR CHAIN N OF ACYLDEPSIPEPTIDE 2