The crystal structue of PDE10A complexed with 1i

2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.

Discovery and Optimization of Chromone Derivatives as Novel Selective Phosphodiesterase 10 Inhibitors.

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

0.1 M Hepes (pH 7.5), 0.2 M MgCl2, 18% PEG 3350, 50 mM 2-mercaptoethanol

National Natural Science Foundation of China

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (E.C.3.1.4.17,3.1.4.35)