Cystal structure of human factor VIII C2 domain in a ternary complex with murine inhbitory antibodies 3E6 and G99

Structure of the factor VIII C2 domain in a ternary complex with 2 inhibitor antibodies reveals classical and nonclassical epitopes.

Antihemophilic factor, AHF, Procoagulant component, Factor VIIIa heavy chain, 200 kDa isoform, Factor VIIIa heavy chain, 92 kDa isoform, Factor VIII B chain, Factor VIIIa light chain

28% PEG-1000, 0.15 M sodium acetate, 0.025 M Tris-HCl, 0.05 M NaCl, 0.15 M ammonium nitrate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K

MURINE MONOCLONAL 3E6 FAB HEAVY CHAIN, MURINE MONOCLONAL 3E6 FAB LIGHT CHAIN, MURINE MONOCLONAL G99 FAB HEAVY CHAIN, MURINE MONOCLONAL G99 FAB LIGHT CHAIN, Coagulation factor VIII

immunoglobulin fold, discoidin fold, antibody, blood coagulation factor, antigen binding, blood plasma, IMMUNE SYSTEM