Structural analysis of DFG-in and DFG-out dual Src-Abl inhibitors sharing a common vinyl purine template

Abelson murine leukemia viral oncogene homolog 1, Proto-oncogene c-Abl, p150

0.1 M TRIS-HCL, pH 8.5, 30% w/v PEG 4000, VAPOR DIFFUSION, HANGING DROP, temperature 277K

Tyrosine-protein kinase transforming protein Abl (E.C.2.7.10.2)

Abl, CML, drug resistance, inhibitor, ATP-binding, Kinase, Nucleotide-binding, Oncogene, Tyrosine-protein kinase, TRANSFERASE