Crystal structure of PI3Kalpha selective Inhibitor PF-06843195

2,2-difluoroethyl (3S)-3-{[2'-amino-5-fluoro-2-(morpholin-4-yl)[4,5'-bipyrimidin]-6-yl]amino}-3-(hydroxymethyl)pyrrolidine-1-carboxylate

Structure-Based Drug Design and Synthesis of PI3K alpha-Selective Inhibitor (PF-06843195).

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

PtdIns-3-kinase subunit alpha,Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha,p110alpha,Phosphoinositide-3-kinase catalytic alpha polypeptide,Serine/threonine protein kinase PIK3CA

8% (w/v) PEG 6000, 0.1 M CHES pH 9.75, 0.64 M sodium formate, 5 mM TCEP pH 7, 50 mM Tris pH 8.0, 100 mM NaCl, 2% Ethylene Glycol

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (E.C.2.7.1.153,2.7.11.1)